Microcephaly-Associated Protein WDR62 Shuttles From the Golgi Apparatus to the Spindle Poles in Human Neural Progenitors

Scientists investigated WDR62 function in corticogenesis through the analysis of a C-terminal truncating mutation. They generated 2D and 3D models of human neurodevelopment, including neuroepithelial stem cells, cerebro-cortical progenitors, terminally differentiated neurons, and cerebral organoids.