1,25-Dihydroxy Vitamin D3 Facilitates the M2 Polarization and β-Amyloid Uptake by Human Microglia in a TREM2-Dependent Manner

Researchers treated human microglial cells with Aβ to mimic in vivo microglial activation and neuroinflammation in response to Aβ accumulation, which are the main pathological features of Alzheimer’s disease, and examined the potential immunomodulatory effects of 1,25(OH)2D3 in vitro.