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Crosstalk between RNA m6A and DNA Methylation Regulates Transposable Element Chromatin Activation and Cell Fate in Human Pluripotent Stem Cells

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Researchers developed a targeted proteomic proximity labeling approach to capture transposable element (TE)-associated proteins in hESCs. They found that the RNA N6-methyladenosine (m6A) reader, YTHDC2, occupied genomic loci of the primate-specific TE, LTR7/HERV-H.
[Nature Genetics]
Abstract
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