NewslettersEndothelial Cell News Repression of rRNA Gene Transcription by Endothelial SPEN Deficiency Normalizes Tumor Vasculature via Nucleolar Stress By Laurisa Dohm - August 28, 2023 0 Scientists showed that split end (SPEN), a transcription repressor, coordinated ribosome RNA synthesis in endothelial cells and was required for physiological and tumor angiogenesis. [Journal Of Clinical Investigation] AbstractFull ArticleGraphical Abstract