NewslettersImmune Regulation News PD-1 Signaling Negatively Regulates the Common Cytokine Receptor γ Chain via MARCH5-Mediated Ubiquitination and Degradation to Suppress Anti-Tumor Immunity By Noshin Noorjahan - November 6, 2023 0 Scientists showed that PD-1 ligation resulted in BATF-dependent transcriptional induction of the membrane-associated E3 ubiquitin ligase MARCH5. [Cell Research] Full Article