Enhanced SREBP2-Driven Cholesterol Biosynthesis by PKCλ/ι Deficiency in Intestinal Epithelial Cells Promotes Aggressive Serrated Tumorigenesis

Researchers demonstrated that the phosphorylation of SCAP by the atypical PKC, PKCλ/ι promote its degradation and inhibits the processing and activation of SREBP2, the master regulator of cholesterol biosynthesis.