Long-Term Activation of Anti-Tumor Immunity in Pancreatic Cancer by a p53-Expressing Telomerase-Specific Oncolytic Adenovirus

Researchers investigated the efficacy of a telomerase-specific oncolytic adenovirus armed with the p53 gene for pancreatic cancer, focusing on its long-term effects via long-lived memory CD8⁺ T cells including tissue-resident memory T cells and effector memory T cells differentiated from effector memory precursor cells.