NewslettersDermal Cell News Age-Dependent Loss of HAPLN1 Erodes Vascular Integrity via Indirect Upregulation of Endothelial ICAM1 in Melanoma By Emily Salmini - March 12, 2024 0 Investigators showed that HAPLN1 in the dermal extracellular matrix was sufficient to maintain the integrity of melanoma-associated blood vessels, as indicated by increased collagen and VE-cadherin expression. [Nature Aging] Abstract