Emily Salmini

[Cell Death Discovery] Investigators evaluated the implication of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) in ultraviolet radiation (UV) B-induced cell death in human diploid dermal fibroblasts, and reported that RIPK3 and MLKL played opposite roles in UVB-induced cell death, in a necroptosis independent pathway.

[Journal Of Investigative Dermatology] Scientists review some of the techniques that have been developed for eliciting cutaneous wounds in the zebrafish, including an economical method they recently developed using a rotary tool that generates consistent and reproducible full-thickness wounds.

[Journal Of Molecular Cell Biology] Using a mouse mammary gland model, investigators delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development.

[PLOS Genetics] Researchers identified Resf1 as a novel metastasis susceptibility gene in ER- breast cancer. Reduction of Resf1 resulted in a significant increase in tumor growth, a shortened overall survival time, and increased incidence and number of lung metastases, consistent with patient data.

[FEBS Journal] Researchers elucidated the role of WDR61 in breast tumor development, and reported that knockdown of WDR61 compromised the proliferation of breast tumor cells with reduced colony-forming capacity.

[Cancer Science] The authors provide a comprehensive review on the clinical features, molecular characteristics, invasion and metastasis patterns, and prognosis of metaplastic breast cancer, as well as recent advancements in treatment strategies.