POLQ Inhibition Attenuates the Stemness and Ferroptosis Resistance in Gastric Cancer Cells via Downregulation of Dihydroorotate Dehydrogenase

The authors reported that polymerase theta (POLQ), a widely conserved DNA polymerase, positively regulated stem cell-like characteristics of gastric cancer (GC) cells. Knockdown of POLQ suppressed the stemness of GC cells in vitro and in vivo.