LSD1 Inhibition Circumvents Glucocorticoid-Induced Muscle Wasting of Male Mice

Researchers showed that glucocorticoid receptor (GR) and the lysine-specific demethylase 1 (LSD1) interact in myofibers of male mice, and that LSD1 connected GR-bound enhancers with NRF1-associated promoters to stimulate target gene expression.