D-Peptide-Magnetic Nanoparticles Fragment Tau Fibrils and Rescue Behavioral Deficits in a Mouse Model of Alzheimer’s Disease

Scientists designed a seven-residue D-TLKIVWC peptide, which not only prevented tau aggregation but also fragmented tau fibrils extracted from Alzheimer’s disease brains to neutralize their seeding ability and protect neuronal cells from tau-induced toxicity.