Suppression of Lysosome Metabolism-Meditated GARP/TGF-β1 Complexes Specifically Depletes Regulatory T Cells to Inhibit Breast Cancer Metastasis

Researchers demonstrated that tumour necrosis factor receptor-associated factor 3 interacting protein 3 (TRAF3IP3) in the Treg lysosome was involved in the activation mechanism of transforming growth factor-β1.