RNA-Sequencing Suggests Extracellular Matrix and Vasculature Dysregulation Could Impair Neurogenesis in Schizophrenia Cases with Elevated Inflammation

Scientists aimed to discover transcriptomic differences between inflammatory subgroups of schizophrenia in the subependymal zone (SEZ). Total RNA sequencing was performed on SEZ tissue from schizophrenia cases, designated into low inflammation and high inflammation subgroups, based on cluster analysis of inflammation marker gene expression.