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The Requirement for Pyruvate Dehydrogenase in Leukemogenesis Depends on Cell Lineage

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Investigators compared glucose metabolism in hematopoiesis and leukemia. Thymus T cell progenitors were glucose avid and oxidized more glucose in the tricarboxylic acid cycle through pyruvate dehydrogenase as compared with other hematopoietic cells.
[Cell Metabolism]
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