Tag results:
T-cell leukemia
Neural Cell News
Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis
[Neurotherapeutics] Individuals with HIV-associated amyotrophic lateral sclerosis (ALS) show a remarkable response to antiretroviral therapy; however, antiretroviral trials in ALS down-regulate HML-2 without ameliorating the disease.
Human Immunology News
Twist Bioscience Signs Antibody Discovery Collaboration with MediSix Therapeutics to Develop T Cell Therapies
[Twist Bioscience Corporation] Twist Bioscience Corporation and MediSix Therapeutics announced a collaboration to discover novel antibodies against five undisclosed targets. Twist will leverage its proprietary Library of Libraries to discover five novel antibodies directed against MediSix’s targets.
Cell Therapy News
Bryostatin Activates CAR T-Cell Antigen-Non-Specific Killing (CTAK), and CAR-T NK-Like Killing for Pre-B ALL, While Blocking Cytolysis of a Burkitt Lymphoma Cell Line
[Frontiers in Immunology] Investigators explored the impact of epigenetic modifiers and differentiation agents on leukemia cell lines of B cell origin, as well as normal B cells.
Hematopoiesis News
Valemetostat New Drug Application Submitted in Japan for Treatment of Patients with Adult T Cell Leukemia/Lymphoma
[Daiichi Sankyo Company, Limited] Daiichi Sankyo Company, Limited announced that it has submitted a New Drug Application to Japan’s Ministry of Health, Labour and Welfare for valemetostat, a potential first-in-class dual inhibitor of EZH1 and EZH2, for the treatment of patients with relapsed/refractory adult T cell leukemia/lymphoma.
Hematopoiesis News
TAS-116 (Pimitespib), an HSP90 Inhibitor, Exhibits Efficacy in Preclinical Models of Adult T Cell Leukemia
[Cancer Science] The authors investigated the anti-adult T cell leukemia/lymphoma effects of a novel oral HSP90 inhibitor TAS-116 and the mechanisms involved in ex vivo and in vivo preclinical models.
Hematopoiesis News
Whole-Genome Landscape of Adult T Cell Leukemia/Lymphoma
[Blood] The authors performed whole-genome sequencing of 150 adult T cell leukemia/lymphoma (ATL) cases and revealed the overarching landscape of genetic alterations in ATL.