Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice.
[Nature Reviews Endocrinology]
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Nair, G. G., Tzanakakis, E. S., & Hebrok, M. (2020). Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy. Nature Reviews Endocrinology, 1–13. https://doi.org/10.1038/s41574-020-0375-3 Cite
