Home Newsletters Cell Therapy News The Promise and Challenges of Cell Therapy for Psoriasis

The Promise and Challenges of Cell Therapy for Psoriasis

0
The authors discuss the various forms of cell therapy currently available, their utility in the management of immune-mediated inflammatory diseases (IMIDs) and emerging evidence for efficacy in severe psoriasis unresponsive to biologic therapy.
[British Journal of Dermatology]
7753456 {7753456:AUUFMC3B} apa 50 1 162822 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-7384a652e8e329f3d5f0b9fcde0d4299%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22AUUFMC3B%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lwin%20et%20al.%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELwin%2C%20S.%20M.%2C%20Snowden%2C%20J.%20A.%2C%20%26amp%3B%20Griffiths%2C%20C.%20E.%20M.%20%28n.d.%29.%20The%20Promise%20and%20Challenges%20of%20Cell%20Therapy%20for%20Psoriasis.%20%3Ci%3EBritish%20Journal%20of%20Dermatology%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbjd.20517%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbjd.20517%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DAUUFMC3B%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Promise%20and%20Challenges%20of%20Cell%20Therapy%20for%20Psoriasis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20M.%22%2C%22lastName%22%3A%22Lwin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20A.%22%2C%22lastName%22%3A%22Snowden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20E.%20M.%22%2C%22lastName%22%3A%22Griffiths%22%7D%5D%2C%22abstractNote%22%3A%22The%20management%20of%20moderate-severe%20psoriasis%20has%20been%20transformed%20by%20the%20introduction%20of%20biologic%20therapies.%20These%20medicines%2C%20particularly%20those%20targeting%20interleukin%20%28IL%29-17%20and%20IL-23p19%2C%20can%20offer%20clear%20or%20nearly%20clear%20skin%20for%20the%20majority%20of%20psoriasis%20patients%2C%20with%20good%20long-term%20drug%20survival.%20However%2C%20as%20currently%20used%2C%20none%20of%20these%20therapies%20is%20curative%20and%20disconcertingly%20there%20is%20a%20small%20but%20increasing%20number%20of%20patients%20with%20severe%20psoriasis%20who%20have%20failed%20all%20currently%20available%20therapeutic%20modalities.%20A%20similar%20scenario%20has%20occurred%20in%20other%20immune-mediated%20inflammatory%20diseases%20%28IMIDs%29%20where%20treatment%20options%20are%20limited%20in%20severely%20affected%20patients%3B%20in%20these%20cases%2C%20cell%20therapy%2C%20including%20haematopoietic%20stem%20cell%20transplantation%20%28HSCT%29%20and%20mesenchymal%20stromal%20cells%20%28MSC%29%2C%20has%20been%20utilised.%20This%20review%20discusses%20the%20various%20forms%20of%20cell%20therapy%20currently%20available%2C%20their%20utility%20in%20the%20management%20of%20IMIDs%20and%20emerging%20evidence%20for%20efficacy%20in%20severe%20psoriasis%20unresponsive%20to%20biologic%20therapy.%20Balancing%20the%20risk-benefits%20of%20treatment%20versus%20the%20underlying%20disease%20is%20key%3B%20cell%20therapy%20carries%20significant%20risks%2C%20costs%2C%20regulation%20and%20other%20complexities%2C%20which%20have%20to%20be%20justified%20by%20outcomes.%20Although%20HSCT%20has%20anecdotally%20been%20reported%20to%20benefit%20severe%20psoriasis%2C%20sometimes%20with%20apparent%20cure%2C%20this%20has%20mainly%20been%20in%20the%20setting%20of%20other%20co-incidental%20%5Cu2018routine%5Cu2019%20indications.%20In%20psoriasis%2C%20cell%20therapies%2C%20such%20as%20MSC%20and%20T%20regulatory%20cells%2C%20with%20a%20lower%20risk%20of%20complications%20are%20likely%20to%20be%20more%20appropriate.%20Well-designed%2C%20controlled%20trials%20coupled%20with%20mechanistic%20studies%20are%20warranted%20if%20advanced%20cell%20therapies%20are%20to%20be%20developed%20and%20delivered%20as%20a%20realistic%20option%20for%20severe%20psoriasis.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbjd.20517%22%2C%22ISSN%22%3A%221365-2133%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fbjd.20517%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22DUPVZUHA%22%5D%2C%22dateModified%22%3A%222021-05-26T14%3A56%3A28Z%22%7D%7D%5D%7D
Lwin, S. M., Snowden, J. A., & Griffiths, C. E. M. (n.d.). The Promise and Challenges of Cell Therapy for Psoriasis. British Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjd.20517 Cite
Full Article
Exit mobile version