Investigators described a novel approach in which human chimeric antigen receptor (CAR T) cells could be generated within the host upon injecting an adeno-associated virus (AAV) vector carrying the CAR gene, which they called AAV delivering CAR gene therapy.
[Blood Cancer Journal]
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Nawaz, W., Huang, B., Xu, S., Li, Y., Zhu, L., Yiqiao, H., Wu, Z., & Wu, X. (2021). AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia. Blood Cancer Journal, 11(6), 1–12. https://doi.org/10.1038/s41408-021-00508-1 Cite
