Home Newsletters Hepatic Cell News The Role of Farnesoid X Receptor in Metabolic Diseases, and Gastrointestinal and...

The Role of Farnesoid X Receptor in Metabolic Diseases, and Gastrointestinal and Liver Cancer

0
Studies on the role of farnesoid X receptor in metabolic diseases and gastrointestinal and liver cancer are discussed, and the potential for development of targeted drugs are summarized.
[Nature Reviews Gastroenterology & Hepatology]
1254621 {1254621:25X3MENW} apa 50 1 158963 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ede1d43f2e5eda62e10251bd8ceaba86%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2225X3MENW%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sun%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESun%2C%20L.%2C%20Cai%2C%20J.%2C%20%26amp%3B%20Gonzalez%2C%20F.%20J.%20%282021%29.%20The%20role%20of%20farnesoid%20X%20receptor%20in%20metabolic%20diseases%2C%20and%20gastrointestinal%20and%20liver%20cancer.%20%3Ci%3ENature%20Reviews%20Gastroenterology%20%26amp%3B%20Hepatology%3C%5C%2Fi%3E%2C%201%26%23x2013%3B13.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41575-020-00404-2%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41575-020-00404-2%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3D25X3MENW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20role%20of%20farnesoid%20X%20receptor%20in%20metabolic%20diseases%2C%20and%20gastrointestinal%20and%20liver%20cancer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lulu%22%2C%22lastName%22%3A%22Sun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jie%22%2C%22lastName%22%3A%22Cai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%20J.%22%2C%22lastName%22%3A%22Gonzalez%22%7D%5D%2C%22abstractNote%22%3A%22Farnesoid%20X%20receptor%20%28FXR%29%20is%20a%20ligand-activated%20transcription%20factor%20involved%20in%20the%20control%20of%20bile%20acid%20%28BA%29%20synthesis%20and%20enterohepatic%20circulation.%20FXR%20can%20influence%20glucose%20and%20lipid%20homeostasis.%20Hepatic%20FXR%20activation%20by%20obeticholic%20acid%20is%20currently%20used%20to%20treat%20primary%20biliary%20cholangitis.%20Late-stage%20clinical%20trials%20investigating%20the%20use%20of%20obeticholic%20acid%20in%20the%20treatment%20of%20nonalcoholic%20steatohepatitis%20are%20underway.%20Mouse%20models%20of%20metabolic%20disease%20have%20demonstrated%20that%20inhibition%20of%20intestinal%20FXR%20signalling%20reduces%20obesity%2C%20insulin%20resistance%20and%20fatty%20liver%20disease%20by%20modulation%20of%20hepatic%20and%20gut%20bacteria-mediated%20BA%20metabolism%2C%20and%20intestinal%20ceramide%20synthesis.%20FXR%20also%20has%20a%20role%20in%20the%20pathogenesis%20of%20gastrointestinal%20and%20liver%20cancers.%20Studies%20using%20tissue-specific%20and%20global%20Fxr-null%20mice%20have%20revealed%20that%20FXR%20acts%20as%20a%20suppressor%20of%20hepatocellular%20carcinoma%2C%20mainly%20through%20regulating%20BA%20homeostasis.%20Loss%20of%20whole-body%20FXR%20potentiates%20progression%20of%20spontaneous%20colorectal%20cancer%2C%20and%20obesity-induced%20BA%20imbalance%20promotes%20intestinal%20stem%20cell%20proliferation%20by%20suppressing%20intestinal%20FXR%20in%20Apcmin%5C%2F%2B%20mice.%20Owing%20to%20altered%20gut%20microbiota%20and%20FXR%20signalling%2C%20changes%20in%20overall%20BA%20levels%20and%20specific%20BA%20metabolites%20probably%20contribute%20to%20enterohepatic%20tumorigenesis.%20Modulating%20intestinal%20FXR%20signalling%20and%20altering%20BA%20metabolites%20are%20potential%20strategies%20for%20gastrointestinal%20and%20liver%20cancer%20prevention%20and%20treatment.%20In%20this%20Review%2C%20studies%20on%20the%20role%20of%20FXR%20in%20metabolic%20diseases%20and%20gastrointestinal%20and%20liver%20cancer%20are%20discussed%2C%20and%20the%20potential%20for%20development%20of%20targeted%20drugs%20are%20summarized.%22%2C%22date%22%3A%222021-02-10%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41575-020-00404-2%22%2C%22ISSN%22%3A%221759-5053%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41575-020-00404-2%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-10T19%3A19%3A07Z%22%7D%7D%5D%7D
Sun, L., Cai, J., & Gonzalez, F. J. (2021). The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. Nature Reviews Gastroenterology & Hepatology, 1–13. https://doi.org/10.1038/s41575-020-00404-2 Cite
Abstract
Exit mobile version