Nomenclature reflecting the mutually opposing nature of T-cell self-renewal and T-cell differentiation would help synchronize phenomena such as T-cell memory, protective immunity, and T-cell exhaustion with other regenerative paradigms, as well as offer new strategies to influence the intensity and duration of immunity.
[Cold Spring Harbor Perspectives in Biology]
6445218
{6445218:CZ53WQ9P}
apa
50
1
164211
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-8359fca0e81551c6f194ddc99a9bda69%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22CZ53WQ9P%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reiner%22%2C%22parsedDate%22%3A%222021-07-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EReiner%2C%20S.%20L.%20%282021%29.%20A%20Regenerative%20Perspective%20on%20Successful%20and%20Failed%20T-Cell%20Immunity.%20%3Ci%3ECold%20Spring%20Harbor%20Perspectives%20in%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E13%3C%5C%2Fi%3E%287%29%2C%20a037937.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2Fcshperspect.a037937%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2Fcshperspect.a037937%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DCZ53WQ9P%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20Regenerative%20Perspective%20on%20Successful%20and%20Failed%20T-Cell%20Immunity%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20L.%22%2C%22lastName%22%3A%22Reiner%22%7D%5D%2C%22abstractNote%22%3A%22Heightened%20immunity%20after%20a%20primary%20infection%2C%20persistent%20control%20of%20low-level%20infection%2C%20or%20vanquished%20immunity%20from%20chronic-active%20infection%20and%20cancer%20are%20interrelated%20issues%20concerning%20the%20nature%20of%20T-cell%20regeneration%20during%20immunity.%20For%20many%20regenerating%20tissues%20and%20cellular%20systems%2C%20such%20as%20epithelia%20and%20blood%2C%20there%20are%20at%20least%20three%20distinguishable%20stages%20of%20development%20and%20repair%2C%20marked%20by%20progressive%20loss%20of%20self-renewal%20and%20progressive%20commitment%20to%20differentiation.%20T%20cells%20seem%20to%20be%20no%20different.%20Quiescent%20precursors%20become%20activated%20and%20yield%20anabolic%2C%20proliferative%20progenitors%20while%20self-renewing%20the%20quiescent%20precursor%20population.%20Activated%20progenitors%20then%20yield%20differentiated%20cellular%20descendants%20alongside%20the%20self-renewal%20of%20progenitors.%20Nomenclature%20reflecting%20the%20mutually%20opposing%20nature%20of%20T-cell%20self-renewal%20and%20T-cell%20differentiation%20would%20help%20synchronize%20phenomena%20such%20as%20T-cell%20memory%2C%20protective%20immunity%2C%20and%20T-cell%20exhaustion%20with%20other%20regenerative%20paradigms%2C%20as%20well%20as%20offer%20new%20strategies%20to%20influence%20the%20intensity%20and%20duration%20of%20immunity.%22%2C%22date%22%3A%2207%5C%2F01%5C%2F2021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1101%5C%2Fcshperspect.a037937%22%2C%22ISSN%22%3A%22%2C%201943-0264%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fcshperspectives.cshlp.org%5C%2Fcontent%5C%2F13%5C%2F7%5C%2Fa037937%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-05T21%3A29%3A24Z%22%7D%7D%5D%7D
Reiner, S. L. (2021). A Regenerative Perspective on Successful and Failed T-Cell Immunity. Cold Spring Harbor Perspectives in Biology, 13(7), a037937. https://doi.org/10.1101/cshperspect.a037937 Cite
