The authors report the activation and repression of innate immune response by SARS-CoV-2. They showed that SARS-CoV-2 RNA activated the RIG-I-MAVS-dependent interferon signaling pathway.
[Cell Reports]
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Wu, J., Shi, Y., Pan, X., Wu, S., Hou, R., Zhang, Y., Zhong, T., Tang, H., Du, W., Wang, L., Wo, J., Mu, J., Qiu, Y., Yang, K., Zhang, L.-K., Ye, B.-C., & Qi, N. (2021). SARS-CoV-2 ORF9b Inhibits RIG-I-MAVS Antiviral Signaling by Interrupting K63-Linked Ubiquitination of NEMO. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2021.108761 Cite
