Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.
[Nature Communications]
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Pereira, J. D., DuBreuil, D. M., Devlin, A.-C., Held, A., Sapir, Y., Berezovski, E., Hawrot, J., Dorfman, K., Chander, V., & Wainger, B. J. (2021). Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions. Nature Communications, 12(1), 4744. https://doi.org/10.1038/s41467-021-24776-4 Cite
