microglia

[Cancer Immunology Research] Scientists showed that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 in glioma stem cells drive immunosuppression in glioblastoma.

[Cell Reports] The authors studied the importance of CCL18, a cytokine expressed in human but not in rodent glioma-associated microglia/macrophages, as a modulator of glioma growth.

[Immunology Letters] The authors summarize the current knowledge on the possible microglial states during development, homeostasis, and perturbation.

[Neuroscience and Biobehavioral Reviews] The authors summarize current knowledge on the impact of astrocyte and microglia activity on behavioral outcomes, with a specific focus on brain areas relevant to higher cognitive control, reward-seeking, and circadian regulation.

[Biomaterials] Exosomes from the conditioned medium (CM) of gingival MSC were isolated by ultracentrifugation and were injected into the vitreous of mice. The results showed that intraocular injection of TNF-α-stimulated gingival MSC into mice with ischemia-reperfusion injury notably reduced inflammation and cell loss than that with G-exos.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that targeting colony stimulating factor 1 (CSF-1) with neutralizing antibody halted ongoing encephalomyelitis, with efficacy superior to colony CSF-1 receptor inhibitor BLZ945, whereas IL-34 neutralization had no effect, suggesting that pathogenic myeloid cells were maintained by CSF-1.