TNF-α Stimulation Enhances the Neuroprotective Effects of Gingival MSCs Derived Exosomes in Retinal Ischemia-Reperfusion Injury via the MEG3/miR-21a-5p Axis

Exosomes from the conditioned medium (CM) of gingival MSC were isolated by ultracentrifugation and were injected into the vitreous of mice. The results showed that intraocular injection of TNF-α-stimulated gingival MSC into mice with ischemia-reperfusion injury notably reduced inflammation and cell loss than that with G-exos.