Molecular Regulation of Trophoblast Stem Cell Self-Renewal and Giant Cell Differentiation by the Hippo Components YAP and LATS1

Trophoblast giant cells differentiation is associated with cytoplasmic retention of YAP, heightened pYAPSer127, decrease in the level of the core Hippo component, LATS1, which thereby impedes LATS1-LIMK2 association.