Researchers discuss the current research advances in strategies to obtain insulin-producing cells from different precursor cells and in stem cell-based therapies for diabetes.
[Stem Cell Research & Therapy]
1254621
{1254621:NWYQ38LZ}
apa
50
1
151635
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-138d3e4e5f88c5631d5d57d484dca62d%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NWYQ38LZ%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chen%20et%20al.%22%2C%22parsedDate%22%3A%222020-07-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EChen%2C%20S.%2C%20Du%2C%20K.%2C%20%26amp%3B%20Zou%2C%20C.%20%282020%29.%20Current%20progress%20in%20stem%20cell%20therapy%20for%20type%201%20diabetes%20mellitus.%20%3Ci%3EStem%20Cell%20Research%20%26amp%3B%20Therapy%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%20275.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-020-01793-6%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-020-01793-6%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3DNWYQ38LZ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Current%20progress%20in%20stem%20cell%20therapy%20for%20type%201%20diabetes%20mellitus%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuai%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kechen%22%2C%22lastName%22%3A%22Du%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunlin%22%2C%22lastName%22%3A%22Zou%22%7D%5D%2C%22abstractNote%22%3A%22Type%201%20diabetes%20mellitus%20%28T1DM%29%20is%20the%20most%20common%20chronic%20autoimmune%20disease%20in%20young%20patients%20and%20is%20characterized%20by%20the%20loss%20of%20pancreatic%20%5Cu03b2%20cells%3B%20as%20a%20result%2C%20the%20body%20becomes%20insulin%20deficient%20and%20hyperglycemic.%20Administration%20or%20injection%20of%20exogenous%20insulin%20cannot%20mimic%20the%20endogenous%20insulin%20secreted%20by%20a%20healthy%20pancreas.%20Pancreas%20and%20islet%20transplantation%20have%20emerged%20as%20promising%20treatments%20for%20reconstructing%20the%20normal%20regulation%20of%20blood%20glucose%20in%20T1DM%20patients.%20However%2C%20a%20critical%20shortage%20of%20pancreases%20and%20islets%20derived%20from%20human%20organ%20donors%2C%20complications%20associated%20with%20transplantations%2C%20high%20cost%2C%20and%20limited%20procedural%20availability%20remain%20bottlenecks%20in%20the%20widespread%20application%20of%20these%20strategies.%20Attempts%20have%20been%20directed%20to%20accommodate%20the%20increasing%20population%20of%20patients%20with%20T1DM.%20Stem%20cell%20therapy%20holds%20great%20potential%20for%20curing%20patients%20with%20T1DM.%20With%20the%20advent%20of%20research%20on%20stem%20cell%20therapy%20for%20various%20diseases%2C%20breakthroughs%20in%20stem%20cell-based%20therapy%20for%20T1DM%20have%20been%20reported.%20However%2C%20many%20unsolved%20issues%20need%20to%20be%20addressed%20before%20stem%20cell%20therapy%20will%20be%20clinically%20feasible%20for%20diabetic%20patients.%20In%20this%20review%2C%20we%20discuss%20the%20current%20research%20advances%20in%20strategies%20to%20obtain%20insulin-producing%20cells%20%28IPCs%29%20from%20different%20precursor%20cells%20and%20in%20stem%20cell-based%20therapies%20for%20diabetes.%22%2C%22date%22%3A%22July%208%2C%202020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13287-020-01793-6%22%2C%22ISSN%22%3A%221757-6512%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-020-01793-6%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-07-10T20%3A15%3A24Z%22%7D%7D%5D%7D
Chen, S., Du, K., & Zou, C. (2020). Current progress in stem cell therapy for type 1 diabetes mellitus. Stem Cell Research & Therapy, 11(1), 275. https://doi.org/10.1186/s13287-020-01793-6 Cite
