Scientists provide an overview of clinical results obtained through the use of haploidentical transplantation in severe aplastic anemia, mainly focusing on current advances and future challenges.
[Bone Marrow Transplantation]
6445218
{6445218:VGYVD32Q}
apa
50
1
157413
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-37ea378e6aa7a3e327fa40dac988e9f8%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22VGYVD32Q%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xu%20and%20Huang%22%2C%22parsedDate%22%3A%222020-12-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EXu%2C%20Z.-L.%2C%20%26amp%3B%20Huang%2C%20X.-J.%20%282020%29.%20Haploidentical%20stem%20cell%20transplantation%20for%20aplastic%20anemia%3A%20the%20current%20advances%20and%20future%20challenges.%20%3Ci%3EBone%20Marrow%20Transplantation%3C%5C%2Fi%3E%2C%201%26%23x2013%3B7.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41409-020-01169-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41409-020-01169-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DVGYVD32Q%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Haploidentical%20stem%20cell%20transplantation%20for%20aplastic%20anemia%3A%20the%20current%20advances%20and%20future%20challenges%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zheng-Li%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao-Jun%22%2C%22lastName%22%3A%22Huang%22%7D%5D%2C%22abstractNote%22%3A%22Haematopoietic%20stem%20cell%20transplantation%20%28HSCT%29%20is%20a%20curative%20option%20for%20severe%20aplastic%20anemia%20%28SAA%29.%20Finding%20a%20suitable%20matched%20donor%20in%20a%20timely%20manner%20is%20a%20challenge.%20The%20availability%20of%20haploidentical%20donors%20and%20their%20successful%20use%20in%20transplantation%20have%20expanded%20valid%20choices%20for%20SAA.%20In%20recent%20decades%2C%20haploidentical%20HSCT%20%28haplo-HSCT%29%20for%20the%20treatment%20of%20SAA%20has%20been%20continuously%20attempted%2C%20and%20great%20strides%20have%20been%20made.%20Nowadays%2C%20haplo-HSCT%20using%20different%20regimens%20has%20overcome%20the%20difficulty%20of%20graft%20failure%20and%20severe%20graft-versus-host%20disease%20%28GvHD%29%2C%20and%20achieved%20inspiring%20survival%20outcomes%20in%20SAA.%20The%20regimens%20consist%20mainly%20of%20granulocyte%20colony-stimulating%20factor%20%28G-CSF%29%20plus%20antithymocyte%20globulin%20%28ATG%29%2C%20posttransplantation%20cyclophosphamide%20%28PT-Cy%29%2C%20and%20ex%20vivo%20graft%20T-cell%20depletion%20%28TCD%29.%20In%20particular%2C%20the%20G-CSF%20and%20ATG-based%20regimen%20includes%20the%20largest%20sample%20size%20and%20the%20successful%20wide%20use%20of%20the%20G-CSF%20and%20ATG-based%20regimen%20has%20promoted%20haplo-HSCT%20a%20higher%20priority%20in%20SAA%20patients%20without%20matched%20related%20or%20unrelated%20donors%20in%20China.%20Recent%20studies%20have%20also%20indicated%20that%20haplo-HSCT%20using%20PT-Cy%20or%20TCD%20regimen%20is%20a%20practicable%20alternative%2C%20but%20the%20sample%20size%20is%20relatively%20small.%20Here%2C%20we%20offer%20an%20overview%20of%20clinical%20results%20obtained%20through%20the%20use%20of%20haploidentical%20transplantation%20in%20SAA%2C%20mainly%20focusing%20on%20current%20advances%20and%20future%20challenges.%22%2C%22date%22%3A%222020-12-15%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41409-020-01169-7%22%2C%22ISSN%22%3A%221476-5365%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41409-020-01169-7%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-12-18T18%3A27%3A41Z%22%7D%7D%5D%7D
Xu, Z.-L., & Huang, X.-J. (2020). Haploidentical stem cell transplantation for aplastic anemia: the current advances and future challenges. Bone Marrow Transplantation, 1–7. https://doi.org/10.1038/s41409-020-01169-7 Cite
