In vivo and in vitro experiments showed that N-docosahexaenoylethanolamine: improved indicators of anxiety and long-term memory; inhibited the pro-inflammatory microglial cells activity; decreased the level of pro-inflammatory cytokines/ROS/NO/nitrites; increased CD206 and superoxide dismutase production.
[Scientific Reports]
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Ponomarenko, A. I., Tyrtyshnaia, A. A., Pislyagin, E. A., Dyuizen, I. V., Sultanov, R. M., & Manzhulo, I. V. (2021). N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Scientific Reports, 11(1), 756. https://doi.org/10.1038/s41598-020-80818-9 Cite
