The authors compare genetics, microbiome, T‐cell infiltrate and resulting epithelial response in psoriasis and atopic dermatitis.
[Journal of Internal Medicine]
6807162
{6807162:77PMLHYB}
apa
50
1
157993
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-936db21bc9f5d48f82ae8b2be440c50d%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2277PMLHYB%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sch%5Cu00e4bitz%20et%20al.%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESch%26%23xE4%3Bbitz%2C%20A.%2C%20Eyerich%2C%20K.%2C%20%26amp%3B%20Garzorz%26%23x2010%3BStark%2C%20N.%20%28n.d.%29.%20So%20close%2C%20and%20yet%20so%20far%20away%3A%20The%20dichotomy%20of%20the%20specific%20immune%20response%20and%20inflammation%20in%20psoriasis%20and%20atopic%20dermatitis.%20%3Ci%3EJournal%20of%20Internal%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjoim.13235%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjoim.13235%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D77PMLHYB%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22So%20close%2C%20and%20yet%20so%20far%20away%3A%20The%20dichotomy%20of%20the%20specific%20immune%20response%20and%20inflammation%20in%20psoriasis%20and%20atopic%20dermatitis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Sch%5Cu00e4bitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Eyerich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Garzorz%5Cu2010Stark%22%7D%5D%2C%22abstractNote%22%3A%22Characterization%20of%20the%20complex%20interplay%20between%20cytokines%2C%20chemokines%20and%20microorganisms%20has%20led%20to%20a%20better%20understanding%20of%20the%20pathogenesis%20of%20both%20psoriasis%20and%20AD%20and%20resulted%20in%20new%20therapeutics%20targeting%20distinct%20immune%20responses.%20Psoriasis%20and%20AD%20share%20many%20characteristics%3A%20they%20are%20highly%20prevalent%2C%20chronic%2C%20cause%20primarily%20skin%20inflammation%2C%20but%20are%20associated%20with%20comorbidities%2C%20and%20come%20with%20a%20devastating%20quality%20of%20life%20due%20to%20itch%20and%20stigmatization.%20However%2C%20the%20pathogenesis%20of%20psoriasis%20and%20AD%20is%20opposing%20%5Cu2013%20psoriasis%20is%20dominated%20by%20a%20Th17%20immune%20response%20that%20causes%20neutrophil%20migration%2C%20induction%20of%20innate%20immunity%20and%20exaggerated%20epithelial%20metabolism.%20Leading%20cytokines%20of%20this%20Th17%20immune%20response%20are%20IL-17A%20and%20F%2C%20IL-22%20and%20TNF-a.%20AD%20is%20characterized%20by%20Th2%20immunity%20characterized%20by%20the%20signature%20cytokines%20IL-4%20and%20IL-13%20leading%20to%20an%20impaired%20epidermal%20barrier%2C%20dampened%20innate%20immunity%20and%20eosinophil%20migration.%20This%20review%20compares%20genetics%2C%20microbiome%20and%20T-cell%20infiltrate%20and%20resulting%20epithelial%20response%20in%20psoriasis%20and%20AD.%20Whilst%20the%20antagonistic%20course%20of%20psoriasis%20and%20AD%20is%20confirmed%20by%20response%20to%20specific%20biologics%20targeting%20the%20key%20cytokines%20of%20inflammation%20in%20psoriasis%20and%20AD%2C%20respectively%2C%20clinically%20overlapping%20phenotypes%20are%20challenging%20in%20our%20daily%20clinical%20practice.%20We%20conclude%20this%20review%20by%20summarizing%20what%20is%20known%20about%20these%20mixed%20phenotypes%20and%20how%20the%20identification%20of%20clinically%20relevant%20endotypes%20and%20molecular-driven%20decision-making%20is%20the%20next%20step%20in%20the%20field%20of%20dermato-immunology.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjoim.13235%22%2C%22ISSN%22%3A%221365-2796%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fjoim.13235%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-01-15T19%3A06%3A59Z%22%7D%7D%5D%7D
Schäbitz, A., Eyerich, K., & Garzorz‐Stark, N. (n.d.). So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13235 Cite
