Tryptophan biosynthesis represents an important potential drug target for new anti-TB drugs. Scientists identified a series of indole-4-carboxamides with potent antitubercular activity.
[Cell Chemical Biology]
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Libardo, M. D. J., Duncombe, C. J., Green, S. R., Wyatt, P. G., Thompson, S., Ray, P. C., Ioerger, T. R., Oh, S., Goodwin, M. B., Boshoff, H. I. M., & Barry, C. E. (2021). Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2021.02.023 Cite
