Home Newsletters Intestinal Cell News Camel Whey Protein Hydrolysates Induced G2/M Cellcycle Arrest in Human Colorectal Carcinoma

Camel Whey Protein Hydrolysates Induced G2/M Cellcycle Arrest in Human Colorectal Carcinoma

0
Peptides from milk proteins is gaining popularity in various therapeutics including human cancer. Researchers investigated the anti-cancerous and anti-inflammatory properties of camel whey protein hydrolysates
[Scientific Reports]
6445212 {6445212:5WCZNV8R} apa 50 1 160652 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-4cf6f2fba4874fc0030ef522b1c45136%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%225WCZNV8R%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Murali%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-29%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMurali%2C%20C.%2C%20Mudgil%2C%20P.%2C%20Gan%2C%20C.-Y.%2C%20Tarazi%2C%20H.%2C%20El-Awady%2C%20R.%2C%20Abdalla%2C%20Y.%2C%20Amin%2C%20A.%2C%20%26amp%3B%20Maqsood%2C%20S.%20%282021%29.%20Camel%20whey%20protein%20hydrolysates%20induced%20G2%5C%2FM%20cellcycle%20arrest%20in%20human%20colorectal%20carcinoma.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%207062.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-86391-z%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-86391-z%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D5WCZNV8R%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Camel%20whey%20protein%20hydrolysates%20induced%20G2%5C%2FM%20cellcycle%20arrest%20in%20human%20colorectal%20carcinoma%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chandraprabha%22%2C%22lastName%22%3A%22Murali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Priti%22%2C%22lastName%22%3A%22Mudgil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chee-Yuen%22%2C%22lastName%22%3A%22Gan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hamadeh%22%2C%22lastName%22%3A%22Tarazi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raafat%22%2C%22lastName%22%3A%22El-Awady%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Youssef%22%2C%22lastName%22%3A%22Abdalla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amr%22%2C%22lastName%22%3A%22Amin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sajid%22%2C%22lastName%22%3A%22Maqsood%22%7D%5D%2C%22abstractNote%22%3A%22Camel%20milk%20has%20been%20gaining%20immmense%20importance%20due%20to%20high%20nutritious%20value%20and%20medicinal%20properties.%20Peptides%20from%20milk%20proteins%20is%20gaining%20popularity%20in%20various%20therapeutics%20including%20human%20cancer.%20The%20study%20was%20aimed%20to%20investigate%20the%20anti-cancerous%20and%20anti-inflammatory%20properties%20of%20camel%20whey%20protein%20hydrolysates%20%28CWPHs%29.%20CWPHs%20were%20generated%20at%20three%20temperatures%20%2830%5Cu00a0%5Cu2103%2C%2037%5Cu00a0%5Cu2103%2C%20and%2045%5Cu00a0%5Cu2103%29%2C%20two%20hydrolysis%20timepoints%20%28120%20and%20360%5Cu00a0min%29%20and%20with%20three%20different%20enzyme%20concentrations%5Cu00a0%280.5%2C%201%20and%5Cu00a02%5Cu00a0%25%29.%20CWPHs%20demonstrated%20an%20increase%20in%20anti-inflammatory%20effect%20between%20732.50%20%28P-6.1%29%20and%203779.16%20%28P-2.1%29%20%5Cu00b5g%20Dicolfenac%20Sodium%20Equivalent%20%28DSE%29%5C%2Fmg%20protein.%20CWPHs%20%28P-4.3%20%26%205.2%29%20inhibited%20growth%20of%20human%20colon%20carcinoma%20cells%20%28HCT116%29%20with%20an%20IC50%20value%20of%20231%20and%20221%5Cu00a0%5Cu03bcg%5C%2Fml%2C%20respectively.%20P-4.3%20induced%20G2%5C%2FM%20cell%20cycle%20arrest%20and%20modulated%20the%20expression%20of%20Cdk1%2C%20p-Cdk1%2C%20Cyclin%20B1%2C%20p-histone%20H3%2C%20p21%20and%20p53.%20Docking%20of%20two%20peptides%20%28AHLEQVLLR%20and%20ALPNIDPPTVER%29%20from%20CWPHs%20%28P-4.3%29%20identified%20Polo%20like%20kinase%201%20as%20a%20potential%20target%2C%20which%20strongly%20supports%20our%20in%20vitro%20data%20and%20provides%20an%20encouraging%20insight%20into%20developing%20a%20novel%20peptide-based%20anticancer%20formulation.%20These%20results%20suggest%20that%20the%20active%20component%2C%20CWPHs%20%28P-4.3%29%2C%20can%20be%20further%20studied%20and%20modeled%20to%20form%20a%20small%20molecule%20anti-cancerous%20therapy.%22%2C%22date%22%3A%222021-03-29%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-86391-z%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-86391-z%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-29T16%3A15%3A23Z%22%7D%7D%5D%7D
Murali, C., Mudgil, P., Gan, C.-Y., Tarazi, H., El-Awady, R., Abdalla, Y., Amin, A., & Maqsood, S. (2021). Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma. Scientific Reports, 11(1), 7062. https://doi.org/10.1038/s41598-021-86391-z Cite
Full Article
Exit mobile version