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p21

ZMAT1 Acts as a Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Inducing SIRT3/p53 Signaling Pathway

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

A Noncoding Regulatory RNA Gm31932 Induces Cell Cycle Arrest and Differentiation in Melanoma via the MiR-344d-3-5p/Prc1 (and Nuf2) Axis

[Cell Death & Disease] Integrative analysis of whole transcriptome sequencing data demonstrated that lncRNA-Gm31932 was significantly decreased in all-trans retinoic acid-induced and sodium 4-phenylbutanoate-induced mouse melanoma B16 cells.

Mechano-Signaling via Piezo1 Prevents Activation and p53-Mediated Senescence of Muscle Stem Cells

[Redox Biology] The authors described that Piezo1, a mechanosensitive ion channel, keeps skeletal muscle stem cells in a quiescent state and prevented senescence.

LncRNA FAF Attenuates Hypoxia/Ischaemia-Induced Pyroptosis via the miR-185-5p/PAK2 Axis in Cardiomyocytes

[Journal of Cellular and Molecular Medicine] Investigators explored the antipyroptotic effects of long noncoding RNA (lncRNA) FGF9-associated factor (FAF) in acute myocardial infarction.

Heterogeneous Nuclear Ribonucleoprotein K Promotes the Progression of Lung Cancer by Inhibiting the p53-Dependent Signaling Pathway

[Thoracic Cancer] Inhibition of progression of lung cancer cells induced by heterogeneous nuclear ribonucleoprotein K-knockdown was dependent on activation of p53 by the p53/p21/cyclin D1 pathway.

The Marine Factor 3,5-Dihydroxy-4-Methoxybenzyl Alcohol Suppresses Growth, Migration and Invasion and Stimulates Death of Metastatic Human Prostate Cancer Cells: Targeting Diverse Signaling Processes

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.

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