Home Newsletters Neural Cell News Astrocytes in Cocaine Addiction and Beyond

Astrocytes in Cocaine Addiction and Beyond

0
Scientists provide a brief overview of the role of astrocytes in regulating synaptic transmission and neuronal function, and discuss how cocaine influences these astrocyte-mediated mechanisms to induce persistent synaptic and circuit alterations that promote cocaine seeking and relapse.
[Molecular Psychiatry]
6807162 {6807162:8N46KUHE} apa 50 1 161045 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-41258e2a36a29dd688419643ba57b015%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228N46KUHE%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wang%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWang%2C%20J.%2C%20Holt%2C%20L.%20M.%2C%20Huang%2C%20H.%20H.%2C%20Sesack%2C%20S.%20R.%2C%20Nestler%2C%20E.%20J.%2C%20%26amp%3B%20Dong%2C%20Y.%20%282021%29.%20Astrocytes%20in%20cocaine%20addiction%20and%20beyond.%20%3Ci%3EMolecular%20Psychiatry%3C%5C%2Fi%3E%2C%201%26%23x2013%3B17.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41380-021-01080-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41380-021-01080-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D8N46KUHE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Astrocytes%20in%20cocaine%20addiction%20and%20beyond%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junshi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leanne%20M.%22%2C%22lastName%22%3A%22Holt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugh%20H.%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%20R.%22%2C%22lastName%22%3A%22Sesack%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20J.%22%2C%22lastName%22%3A%22Nestler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Dong%22%7D%5D%2C%22abstractNote%22%3A%22Drug%20addiction%20remains%20a%20key%20biomedical%20challenge%20facing%20current%20neuroscience%20research.%20In%20addition%20to%20neural%20mechanisms%2C%20the%20focus%20of%20the%20vast%20majority%20of%20studies%20to%20date%2C%20astrocytes%20have%20been%20increasingly%20recognized%20as%20an%20%5Cu201caccomplice.%5Cu201d%20According%20to%20the%20tripartite%20synapse%20model%2C%20astrocytes%20critically%20regulate%20nearby%20pre-%20and%20postsynaptic%20neuronal%20substrates%20to%20craft%20experience-dependent%20synaptic%20plasticity%2C%20including%20synapse%20formation%20and%20elimination.%20Astrocytes%20within%20brain%20regions%20that%20are%20implicated%20in%20drug%20addiction%20exhibit%20dynamic%20changes%20in%20activity%20upon%20exposure%20to%20cocaine%20and%20subsequently%20undergo%20adaptive%20changes%20themselves%20during%20chronic%20drug%20exposure.%20Recent%20results%20have%20identified%20several%20key%20astrocytic%20signaling%20pathways%20that%20are%20involved%20in%20cocaine-induced%20synaptic%20and%20circuit%20adaptations.%20In%20this%20review%2C%20we%20provide%20a%20brief%20overview%20of%20the%20role%20of%20astrocytes%20in%20regulating%20synaptic%20transmission%20and%20neuronal%20function%2C%20and%20discuss%20how%20cocaine%20influences%20these%20astrocyte-mediated%20mechanisms%20to%20induce%20persistent%20synaptic%20and%20circuit%20alterations%20that%20promote%20cocaine%20seeking%20and%20relapse.%20We%20also%20consider%20the%20therapeutic%20potential%20of%20targeting%20astrocytic%20substrates%20to%20ameliorate%20drug-induced%20neuroplasticity%20for%20behavioral%20benefits.%20While%20primarily%20focusing%20on%20cocaine-induced%20astrocytic%20responses%2C%20we%20also%20include%20brief%20discussion%20of%20other%20drugs%20of%20abuse%20where%20data%20are%20available.%22%2C%22date%22%3A%222021-04-09%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41380-021-01080-7%22%2C%22ISSN%22%3A%221476-5578%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41380-021-01080-7%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-09T23%3A56%3A45Z%22%7D%7D%5D%7D
Wang, J., Holt, L. M., Huang, H. H., Sesack, S. R., Nestler, E. J., & Dong, Y. (2021). Astrocytes in cocaine addiction and beyond. Molecular Psychiatry, 1–17. https://doi.org/10.1038/s41380-021-01080-7 Cite
Abstract
Exit mobile version