Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.
[Scientific Reports]
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Mullegama, S. V., Klein, S. D., Williams, S. R., Innis, J. W., Probst, F. J., Haldeman-Englert, C., Martinez-Agosto, J. A., Yang, Y., Tian, Y., Elsea, S. H., & Ezashi, T. (2021). Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes. Scientific Reports, 11(1), 11295. https://doi.org/10.1038/s41598-021-90798-z Cite
