TGFβ

[Cell Reports] Scientists showed that during alveologenesis, Hedgehog-responsive PDGFRa(+) progenitors were a source of secreted trophic molecules that maintained a unique lung alveolar type 2 progenitor population.

[Scientific Reports] Researchers engineered cell sheets to develop a new in vitro model of ballooned hepatocytes.

[Cell Death & Disease] Investigators found that N-(3-aminopropyl)-2-[(3-methylphenyl) methoxy]-N-(2-thienylmethyl) benzamide hydrochloride (AMTB) suppressed osteosarcoma cell proliferation, metastasis and induced cellular apoptosis.

[Molecular Oncology] Whether TGFβ promoted stemness and invasiveness simultaneously via epithelial-mesenchymal transition remained unclear. They established a breast cancer cell model expressing red fluorescent protein under the E-cadherin promoter.

[Acta Pharmacologica Sinica] IMM-H007 attenuated isoprenaline-induced cardiac fibrosis, diastolic dysfunction, α-smooth muscle actin expression, and collagen I deposition in both wild-type and AMP-activated protein kinase α2−/− mice.

[Matrix Biology] Scientists defined type III Collagen as a suppressor of scar formation and desmoplasia through its effects, in part, on myofibroblasts.