Bax Inhibitor-1 Preserves Pancreatic β-Cell Proteostasis by Limiting Proinsulin Misfolding and Programmed Cell Death

Investigators uncovered a new role for bax inhibitor-one, a negative regulator of inositol-requiring enzyme 1 in preserving β-cell health against terminal unfolded protein response (UPR)-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production.