Investigators generated a ubiquitin-specific protease 3 gene knockout using the CRISPR/Cas9 system and demonstrated that USP3 acts as a protein stabilizer of Oct4 by deubiquitinating Oct4.
[International Journal of Molecular Sciences]
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Rhie, B.-H., Antao, A. M., Karapurkar, J. K., Kim, M.-S., Jo, W.-J., Ramakrishna, S., & Kim, K.-S. (2021). Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells. International Journal of Molecular Sciences, 22(11), 5584. https://doi.org/10.3390/ijms22115584 Cite
