gene knockout

[Hepatology] Researchers performed single-cell RNA-sequencing using AKT/NICD-induced mouse intrahepatic cholangiocarcinoma tissues at early, middle, and late stages.

[Liver International] 3-Mercaptopyruvate sulfurtransferase (MPST) protein expression was analyzed in HCC tumor tissues and matched adjacent tissues. The effect of MPST on HCC progression was studied in vitro and in vivo.

[Scientific Reports] Gene knockout studies revealed that SOX2 was an essential factor for the generation of CSCs by HRASV12 in mouse and human fibroblasts.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Kinase inhibitor of IRE1α treatment increased the differentiation of Krt19CreERT2-lineage-traced damage-associated transient progenitors (DATPs) into type 1 alveolar epithelial cells after bleomycin injury, indicating that relief from IRE1α signaling enabled DATPs to exit the transitional state.

[Laboratory Investigation] Scientists showed that collagen XVII, a niche for epidermal stem cells, helped stabilize epidermal patterns.

[Cell Death & Disease] To investigate the role of myeloid cell MANF in the pathogenesis of AILI, researchers assayed serum and liver samples from acetaminophen-induced liver injury model mice and patients with drug-induced liver injury.