Structural Insights into the Cross-Neutralization of SARS-CoV and SARS-CoV-2 by the Human Monoclonal Antibody 47D1

The authors report ed cryo-EM structures of both trimeric spike ectodomains in complex with the 47D11 Fab. 47D11 bound to the closed receptor-binding domain, distal to the ACE2 binding site.