The tumor suppressing effects of MPDZ were determined in vitro and in vivo. The target molecules and signaling pathway that mediated the function of MPDZ were also identified.
[Oncogene]
7753456
QKFZB2XV
items
1
apa
0
default
asc
1
163280
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-dbc34b64b2c8dc06ab782a0e8a36adae%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22QKFZB2XV%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELiu%2C%20W.%2C%20Huang%2C%20Y.%2C%20Wang%2C%20D.%2C%20Han%2C%20F.%2C%20Chen%2C%20H.%2C%20Chen%2C%20J.%2C%20Jiang%2C%20X.%2C%20Cao%2C%20J.%2C%20%26amp%3B%20Liu%2C%20J.%20%282021%29.%20MPDZ%20as%20a%20novel%20epigenetic%20silenced%20tumor%20suppressor%20inhibits%20growth%20and%20progression%20of%20lung%20cancer%20through%20the%20Hippo-YAP%20pathway.%20%3Ci%3EOncogene%3C%5C%2Fi%3E%2C%201%26%23x2013%3B18.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41388-021-01857-8%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41388-021-01857-8%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DQKFZB2XV%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MPDZ%20as%20a%20novel%20epigenetic%20silenced%20tumor%20suppressor%20inhibits%20growth%20and%20progression%20of%20lung%20cancer%20through%20the%20Hippo-YAP%20pathway%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenbin%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yongsheng%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dandan%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fei%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongqiang%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jianping%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jia%22%2C%22lastName%22%3A%22Cao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinyi%22%2C%22lastName%22%3A%22Liu%22%7D%5D%2C%22abstractNote%22%3A%22MPDZ%20also%20named%20MUPP1%20is%20involved%20in%20signal%20transduction%20mediated%20by%20the%20formation%20of%20protein%20complexes.%20However%2C%20the%20expression%20regulation%2C%20clinical%20significance%2C%20potential%20function%2C%20and%20mechanism%20of%20this%20gene%20in%20lung%20cancer%20remain%20unclear.%20Methylation%20status%20of%20MPDZ%20was%20measured%20by%20methylation-specific%20PCR%20and%20bisulfite%20genomic%20sequencing.%20Kaplan%5Cu2013Meier%20and%20Cox%20regression%20analyses%20were%20performed%20to%20identify%20the%20prognostic%20value%20of%20MPDZ.%20The%20tumor%20suppressing%20effects%20of%20MPDZ%20were%20determined%20in%20vitro%20and%20in%20vivo.%20The%20target%20molecules%20and%20signaling%20pathway%20that%20mediated%20the%20function%20of%20MPDZ%20were%20also%20identified.%20MPDZ%20methylation%20was%20identified%20in%2061.2%25%20of%20primary%20lung%20cancer%20tissues%20and%20most%20lung%20cancer%20cell%20lines%20but%20not%20in%20normal%20lung%20tissues.%20MPDZ%20expression%20was%20significantly%20downregulated%20in%20lung%20cancer%20tissues%20and%20negatively%20associated%20with%20DNA%20hypermethylation%2C%20and%20attenuated%20MPDZ%20expression%20predicted%20a%20poor%20outcome.%20Furthermore%2C%20MPDZ%20overexpression%20prominently%20dampened%20cell%20growth%2C%20migration%2C%20and%20invasion%20of%20tumor%20cells.%20Conversely%2C%20MPDZ%20knockdown%20promoted%20cell%20proliferation%2C%20migration%2C%20and%20invasion%20in%20vitro%20and%20in%20vivo.%20Moreover%2C%20MPDZ%20deficiency%20promotes%20tumor%20metastasis%20and%20reduces%20the%20survival%20of%20MPDZ%20knockout%20mice.%20Importantly%2C%20MPDZ%20promotes%20tumor%20suppressor%20ability%20that%20depends%20on%20the%20Hippo%20pathway-mediated%20repression%20of%20YAP.%20MPDZ%20activates%20the%20phosphorylation%20of%20YAP%20%28Ser127%29%20and%20inhibits%20YAP%20expression%20through%20stabilizing%20MST1%20and%20interaction%20with%20LATS1.%20We%20first%20identified%20and%20validated%20that%20MPDZ%20methylation%20and%20expression%20could%20be%20a%20good%20diagnostic%20marker%20and%20independent%20prognostic%20factor%20for%20lung%20cancer.%20MPDZ%20functions%20as%20a%20tumor%20suppressor%20by%20inhibiting%20cell%20proliferation%2C%20migration%2C%20and%20invasion%20through%20regulating%20the%20Hippo-YAP%20signaling%20pathway.%22%2C%22date%22%3A%222021-06-09%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41388-021-01857-8%22%2C%22ISSN%22%3A%221476-5594%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41388-021-01857-8%22%2C%22collections%22%3A%5B%2243ZBJFKZ%22%5D%2C%22dateModified%22%3A%222021-06-09T16%3A36%3A44Z%22%7D%7D%5D%7D
Liu, W., Huang, Y., Wang, D., Han, F., Chen, H., Chen, J., Jiang, X., Cao, J., & Liu, J. (2021). MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway. Oncogene, 1–18. https://doi.org/10.1038/s41388-021-01857-8 Cite
