Researchers showed that the SARS-CoV-2 envelope protein alone is able to cause acute respiratory distress syndrome-like damages in vitro and in vivo.
[Cell Research]
6445218
{6445218:J2LDQIVU}
apa
50
1
163314
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-a951532dd1a93d7d824fc36a8efe2f89%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22J2LDQIVU%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xia%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-10%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EXia%2C%20B.%2C%20Shen%2C%20X.%2C%20He%2C%20Y.%2C%20Pan%2C%20X.%2C%20Liu%2C%20F.-L.%2C%20Wang%2C%20Y.%2C%20Yang%2C%20F.%2C%20Fang%2C%20S.%2C%20Wu%2C%20Y.%2C%20Duan%2C%20Z.%2C%20Zuo%2C%20X.%2C%20Xie%2C%20Z.%2C%20Jiang%2C%20X.%2C%20Xu%2C%20L.%2C%20Chi%2C%20H.%2C%20Li%2C%20S.%2C%20Meng%2C%20Q.%2C%20Zhou%2C%20H.%2C%20Zhou%2C%20Y.%2C%20%26%23x2026%3B%20Gao%2C%20Z.%20%282021%29.%20SARS-CoV-2%20envelope%20protein%20causes%20acute%20respiratory%20distress%20syndrome%20%28ARDS%29-like%20pathological%20damages%20and%20constitutes%20an%20antiviral%20target.%20%3Ci%3ECell%20Research%3C%5C%2Fi%3E%2C%201%26%23x2013%3B14.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41422-021-00519-4%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41422-021-00519-4%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DJ2LDQIVU%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22SARS-CoV-2%20envelope%20protein%20causes%20acute%20respiratory%20distress%20syndrome%20%28ARDS%29-like%20pathological%20damages%20and%20constitutes%20an%20antiviral%20target%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bingqing%22%2C%22lastName%22%3A%22Xia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xurui%22%2C%22lastName%22%3A%22Shen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yang%22%2C%22lastName%22%3A%22He%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyan%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng-Liang%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feipu%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sui%22%2C%22lastName%22%3A%22Fang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zilei%22%2C%22lastName%22%3A%22Duan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoli%22%2C%22lastName%22%3A%22Zuo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhuqing%22%2C%22lastName%22%3A%22Xie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiangrui%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ling%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hao%22%2C%22lastName%22%3A%22Chi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuangqu%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Meng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hu%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yubo%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xi%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoming%22%2C%22lastName%22%3A%22Xin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lin%22%2C%22lastName%22%3A%22Jin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hai-Lin%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan-Dan%22%2C%22lastName%22%3A%22Yu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ming-Hua%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao-Li%22%2C%22lastName%22%3A%22Feng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiekai%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hualiang%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gengfu%22%2C%22lastName%22%3A%22Xiao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yong-Tang%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lei-Ke%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jingshan%22%2C%22lastName%22%3A%22Shen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jia%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhaobing%22%2C%22lastName%22%3A%22Gao%22%7D%5D%2C%22abstractNote%22%3A%22Cytokine%20storm%20and%20multi-organ%20failure%20are%20the%20main%20causes%20of%20SARS-CoV-2-related%20death.%20However%2C%20the%20origin%20of%20excessive%20damages%20caused%20by%20SARS-CoV-2%20remains%20largely%20unknown.%20Here%20we%20show%20that%20the%20SARS-CoV-2%20envelope%20%282-E%29%20protein%20alone%20is%20able%20to%20cause%20acute%20respiratory%20distress%20syndrome%20%28ARDS%29-like%20damages%20in%20vitro%20and%20in%20vivo.%202-E%20proteins%20were%20found%20to%20form%20a%20type%20of%20pH-sensitive%20cation%20channels%20in%20bilayer%20lipid%20membranes.%20As%20observed%20in%20SARS-CoV-2-infected%20cells%2C%20heterologous%20expression%20of%202-E%20channels%20induced%20rapid%20cell%20death%20in%20various%20susceptible%20cell%20types%20and%20robust%20secretion%20of%20cytokines%20and%20chemokines%20in%20macrophages.%20Intravenous%20administration%20of%20purified%202-E%20protein%20into%20mice%20caused%20ARDS-like%20pathological%20damages%20in%20lung%20and%20spleen.%20A%20dominant%20negative%20mutation%20lowering%202-E%20channel%20activity%20attenuated%20cell%20death%20and%20SARS-CoV-2%20production.%20Newly%20identified%20channel%20inhibitors%20exhibited%20potent%20anti-SARS-CoV-2%20activity%20and%20excellent%20cell%20protective%20activity%20in%20vitro%20and%20these%20activities%20were%20positively%20correlated%20with%20inhibition%20of%202-E%20channel.%20Importantly%2C%20prophylactic%20and%20therapeutic%20administration%20of%20the%20channel%20inhibitor%20effectively%20reduced%20both%20the%20viral%20load%20and%20secretion%20of%20inflammation%20cytokines%20in%20lungs%20of%20SARS-CoV-2-infected%20transgenic%20mice%20expressing%20human%20angiotensin-converting%20enzyme%202%20%28hACE-2%29.%20Our%20study%20supports%20that%202-E%20is%20a%20promising%20drug%20target%20against%20SARS-CoV-2.%22%2C%22date%22%3A%222021-06-10%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41422-021-00519-4%22%2C%22ISSN%22%3A%221748-7838%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41422-021-00519-4%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-10T21%3A45%3A04Z%22%7D%7D%5D%7D
Xia, B., Shen, X., He, Y., Pan, X., Liu, F.-L., Wang, Y., Yang, F., Fang, S., Wu, Y., Duan, Z., Zuo, X., Xie, Z., Jiang, X., Xu, L., Chi, H., Li, S., Meng, Q., Zhou, H., Zhou, Y., … Gao, Z. (2021). SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Cell Research, 1–14. https://doi.org/10.1038/s41422-021-00519-4 Cite
