To identify mechanisms of resistance to Mycobacterium tuberculosis (Mtb) infection, scientists compared transcriptional profiles from highly-exposed contacts who resist tuberculin skin test/interferon-γ release assay conversion and controls with latent Mtb infection using RNAseq.
[Journal of Clinical Investigation]
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Simmons, J. D., Van, P. T., Stein, C. M., Chihota, V., Ntshiqa, T., Maenetje, P., Peterson, G. J., Reynolds, A., Benchek, P., Velen, K., Fielding, K. L., Grant, A. D., Graustein, A. D., Nguyen, F. K., Seshadri, C., Gottardo, R., Mayanja-Kizza, H., Wallis, R. S., Churchyard, G., … Hawn, T. R. (2021). Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140073 Cite
