Home Newsletters Immunology of Infectious Disease News Structural Specificities of Cell Surface β-Glucan Polysaccharides Determine Commensal Yeast Mediated Immuno-Modulatory...

Structural Specificities of Cell Surface β-Glucan Polysaccharides Determine Commensal Yeast Mediated Immuno-Modulatory Activities

0
MGCP, in contrast to previously identified microbial cell surface polysaccharides, through a Dectin1-Cox2 signaling axis in dendritic cells, facilitates regulatory T cell induction from naïve T cells.
[Nature Communications]
6445218 {6445218:JG24PLJM} apa 50 1 163371 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-b27e5bfe3a7ebe974c769159e1f3239f%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22JG24PLJM%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lee%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-14%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELee%2C%20C.%2C%20Verma%2C%20R.%2C%20Byun%2C%20S.%2C%20Jeun%2C%20E.-J.%2C%20Kim%2C%20G.-C.%2C%20Lee%2C%20S.%2C%20Kang%2C%20H.-J.%2C%20Kim%2C%20C.%20J.%2C%20Sharma%2C%20G.%2C%20Lahiri%2C%20A.%2C%20Paul%2C%20S.%2C%20Kim%2C%20K.%20S.%2C%20Hwang%2C%20D.%20S.%2C%20Iwakura%2C%20Y.%2C%20Speciale%2C%20I.%2C%20Molinaro%2C%20A.%2C%20De%20Castro%2C%20C.%2C%20Rudra%2C%20D.%2C%20%26amp%3B%20Im%2C%20S.-H.%20%282021%29.%20Structural%20specificities%20of%20cell%20surface%20%26%23x3B2%3B-glucan%20polysaccharides%20determine%20commensal%20yeast%20mediated%20immuno-modulatory%20activities.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%203611.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-23929-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-23929-9%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DJG24PLJM%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Structural%20specificities%20of%20cell%20surface%20%5Cu03b2-glucan%20polysaccharides%20determine%20commensal%20yeast%20mediated%20immuno-modulatory%20activities%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Changhon%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ravi%22%2C%22lastName%22%3A%22Verma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seohyun%22%2C%22lastName%22%3A%22Byun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eun-Ji%22%2C%22lastName%22%3A%22Jeun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gi-Cheon%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suyoung%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hye-Ji%22%2C%22lastName%22%3A%22Kang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chan%20Johng%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garima%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abhishake%22%2C%22lastName%22%3A%22Lahiri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandip%22%2C%22lastName%22%3A%22Paul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kwang%20Soon%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dong%20Soo%22%2C%22lastName%22%3A%22Hwang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoichiro%22%2C%22lastName%22%3A%22Iwakura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Immacolata%22%2C%22lastName%22%3A%22Speciale%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonio%22%2C%22lastName%22%3A%22Molinaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22De%20Castro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dipayan%22%2C%22lastName%22%3A%22Rudra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sin-Hyeog%22%2C%22lastName%22%3A%22Im%22%7D%5D%2C%22abstractNote%22%3A%22Yeast%20is%20an%20integral%20part%20of%20mammalian%20microbiome%2C%20and%20like%20commensal%20bacteria%2C%20has%20the%20potential%20of%20being%20harnessed%20to%20influence%20immunity%20in%20clinical%20settings.%20However%2C%20functional%20specificities%20of%20yeast-derived%20immunoregulatory%20molecules%20remain%20elusive.%20Here%20we%20find%20that%20while%20under%20steady%20state%2C%20%5Cu03b2-1%2C3-glucan-containing%20polysaccharides%20potentiate%20pro-inflammatory%20properties%2C%20a%20relatively%20less%20abundant%20class%20of%20cell%20surface%20polysaccharides%2C%20dubbed%20mannan%5C%2F%5Cu03b2-1%2C6-glucan-containing%20polysaccharides%20%28MGCP%29%2C%20is%20capable%20of%20exerting%20potent%20anti-inflammatory%20effects%20to%20the%20immune%20system.%20MGCP%2C%20in%20contrast%20to%20previously%20identified%20microbial%20cell%20surface%20polysaccharides%2C%20through%20a%20Dectin1-Cox2%20signaling%20axis%20in%20dendritic%20cells%2C%20facilitates%20regulatory%20T%20%28Treg%29%20cell%20induction%20from%20na%5Cu00efve%20T%20cells.%20Furthermore%2C%20through%20a%20TLR2-dependent%20mechanism%2C%20it%20restrains%20Th1%20differentiation%20of%20effector%20T%20cells%20by%20suppressing%20IFN-%5Cu03b3%20expression.%20As%20a%20result%2C%20administration%20of%20MGCP%20display%20robust%20suppressive%20capacity%20towards%20experimental%20inflammatory%20disease%20models%20of%20colitis%20and%20experimental%20autoimmune%20encephalomyelitis%20%28EAE%29%20in%20mice%2C%20thereby%20highlighting%20its%20potential%20therapeutic%20utility%20against%20clinically%20relevant%20autoimmune%20diseases.%22%2C%22date%22%3A%222021-06-14%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-021-23929-9%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-021-23929-9%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-14T18%3A08%3A06Z%22%7D%7D%5D%7D
Lee, C., Verma, R., Byun, S., Jeun, E.-J., Kim, G.-C., Lee, S., Kang, H.-J., Kim, C. J., Sharma, G., Lahiri, A., Paul, S., Kim, K. S., Hwang, D. S., Iwakura, Y., Speciale, I., Molinaro, A., De Castro, C., Rudra, D., & Im, S.-H. (2021). Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities. Nature Communications, 12(1), 3611. https://doi.org/10.1038/s41467-021-23929-9 Cite
Full Article
Exit mobile version