Home Newsletters Immunology of Infectious Disease News Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

0
The authors explored the set of computationally predicted SARS-CoV-2 HLA-I and HLA-II ligands, examining protein source, concurrent human/murine coverage, and population coverage.
[Genome Medicine]
6445218 PTQA36HS items 1 apa 0 default asc 1 163487 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-af4e8487716c943688efea143bd7dd0c%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22PTQA36HS%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Smith%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-14%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESmith%2C%20C.%20C.%2C%20Olsen%2C%20K.%20S.%2C%20Gentry%2C%20K.%20M.%2C%20Sambade%2C%20M.%2C%20Beck%2C%20W.%2C%20Garness%2C%20J.%2C%20Entwistle%2C%20S.%2C%20Willis%2C%20C.%2C%20Vensko%2C%20S.%2C%20Woods%2C%20A.%2C%20Fini%2C%20M.%2C%20Carpenter%2C%20B.%2C%20Routh%2C%20E.%2C%20Kodysh%2C%20J.%2C%20O%26%23x2019%3BDonnell%2C%20T.%2C%20Haber%2C%20C.%2C%20Heiss%2C%20K.%2C%20Stadler%2C%20V.%2C%20Garrison%2C%20E.%2C%20%26%23x2026%3B%20Rubinsteyn%2C%20A.%20%282021%29.%20Landscape%20and%20selection%20of%20vaccine%20epitopes%20in%20SARS-CoV-2.%20%3Ci%3EGenome%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E13%3C%5C%2Fi%3E%281%29%2C%20101.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13073-021-00910-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13073-021-00910-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DPTQA36HS%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Landscape%20and%20selection%20of%20vaccine%20epitopes%20in%20SARS-CoV-2%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christof%20C.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelly%20S.%22%2C%22lastName%22%3A%22Olsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaylee%20M.%22%2C%22lastName%22%3A%22Gentry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Sambade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Beck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%22%2C%22lastName%22%3A%22Garness%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Entwistle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caryn%22%2C%22lastName%22%3A%22Willis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%22%2C%22lastName%22%3A%22Vensko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Allison%22%2C%22lastName%22%3A%22Woods%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Misha%22%2C%22lastName%22%3A%22Fini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brandon%22%2C%22lastName%22%3A%22Carpenter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Routh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Kodysh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%22%2C%22lastName%22%3A%22O%5Cu2019Donnell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%22%2C%22lastName%22%3A%22Haber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kirsten%22%2C%22lastName%22%3A%22Heiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Stadler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22Garrison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%20M.%22%2C%22lastName%22%3A%22Sandor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenny%20P.%20Y.%22%2C%22lastName%22%3A%22Ting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jared%22%2C%22lastName%22%3A%22Weiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krzysztof%22%2C%22lastName%22%3A%22Krajewski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%20C.%22%2C%22lastName%22%3A%22Grant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20J.%22%2C%22lastName%22%3A%22Woods%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20G.%22%2C%22lastName%22%3A%22Vincent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alex%22%2C%22lastName%22%3A%22Rubinsteyn%22%7D%5D%2C%22abstractNote%22%3A%22Early%20in%20the%20pandemic%2C%20we%20designed%20a%20SARS-CoV-2%20peptide%20vaccine%20containing%20epitope%20regions%20optimized%20for%20concurrent%20B%20cell%2C%20CD4%2B%20T%20cell%2C%20and%20CD8%2B%20T%20cell%20stimulation.%20The%20rationale%20for%20this%20design%20was%20to%20drive%20both%20humoral%20and%20cellular%20immunity%20with%20high%20specificity%20while%20avoiding%20undesired%20effects%20such%20as%20antibody-dependent%20enhancement%20%28ADE%29.%22%2C%22date%22%3A%22June%2014%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13073-021-00910-1%22%2C%22ISSN%22%3A%221756-994X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13073-021-00910-1%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-15T22%3A48%3A30Z%22%7D%7D%5D%7D
Smith, C. C., Olsen, K. S., Gentry, K. M., Sambade, M., Beck, W., Garness, J., Entwistle, S., Willis, C., Vensko, S., Woods, A., Fini, M., Carpenter, B., Routh, E., Kodysh, J., O’Donnell, T., Haber, C., Heiss, K., Stadler, V., Garrison, E., … Rubinsteyn, A. (2021). Landscape and selection of vaccine epitopes in SARS-CoV-2. Genome Medicine, 13(1), 101. https://doi.org/10.1186/s13073-021-00910-1 Cite
Full Article
Exit mobile version