The design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets, highlighting distinct design parameters.
[Advanced Science]
7753456
{7753456:IWQIT6UM}
apa
50
1
163731
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-fe2e798f9aa83b3d387b648959c0a199%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22IWQIT6UM%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Goswami%20et%20al.%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGoswami%2C%20D.%2C%20Domingo-Lopez%2C%20D.%20A.%2C%20Ward%2C%20N.%20A.%2C%20Millman%2C%20J.%20R.%2C%20Duffy%2C%20G.%20P.%2C%20Dolan%2C%20E.%20B.%2C%20%26amp%3B%20Roche%2C%20E.%20T.%20%28n.d.%29.%20Design%20Considerations%20for%20Macroencapsulation%20Devices%20for%20Stem%20Cell%20Derived%20Islets%20for%20the%20Treatment%20of%20Type%201%20Diabetes.%20%3Ci%3EAdvanced%20Science%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29%2C%202100820.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadvs.202100820%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadvs.202100820%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DIWQIT6UM%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Design%20Considerations%20for%20Macroencapsulation%20Devices%20for%20Stem%20Cell%20Derived%20Islets%20for%20the%20Treatment%20of%20Type%201%20Diabetes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debkalpa%22%2C%22lastName%22%3A%22Goswami%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20A.%22%2C%22lastName%22%3A%22Domingo-Lopez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niamh%20A.%22%2C%22lastName%22%3A%22Ward%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%20R.%22%2C%22lastName%22%3A%22Millman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garry%20P.%22%2C%22lastName%22%3A%22Duffy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eimear%20B.%22%2C%22lastName%22%3A%22Dolan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%20T.%22%2C%22lastName%22%3A%22Roche%22%7D%5D%2C%22abstractNote%22%3A%22Stem%20cell%20derived%20insulin%20producing%20cells%20or%20islets%20have%20shown%20promise%20in%20reversing%20Type%201%20Diabetes%20%28T1D%29%2C%20yet%20successful%20transplantation%20currently%20necessitates%20long-term%20modulation%20with%20immunosuppressant%20drugs.%20An%20alternative%20approach%20to%20avoiding%20this%20immune%20response%20is%20to%20utilize%20an%20islet%20macroencapsulation%20device%2C%20where%20islets%20are%20incorporated%20into%20a%20selectively%20permeable%20membrane%20that%20can%20protect%20the%20transplanted%20cells%20from%20acute%20host%20response%2C%20whilst%20enabling%20delivery%20of%20insulin.%20These%20macroencapsulation%20systems%20have%20to%20meet%20a%20number%20of%20stringent%20and%20challenging%20design%20criteria%20in%20order%20to%20achieve%20the%20ultimate%20goal%20of%20reversing%20T1D.%20In%20this%20progress%20report%2C%20the%20design%20considerations%20and%20functional%20requirements%20of%20macroencapsulation%20systems%20are%20reviewed%2C%20specifically%20for%20stem-cell%20derived%20islets%20%28SC-islets%29%2C%20highlighting%20distinct%20design%20parameters.%20Additionally%2C%20a%20perspective%20on%20the%20future%20for%20macroencapsulation%20systems%20is%20given%2C%20and%20how%20incorporating%20continuous%20sensing%20and%20closed-loop%20feedback%20can%20be%20transformative%20in%20advancing%20toward%20an%20autonomous%20biohybrid%20artificial%20pancreas.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadvs.202100820%22%2C%22ISSN%22%3A%222198-3844%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fadvs.202100820%22%2C%22collections%22%3A%5B%223XSKJF5U%22%5D%2C%22dateModified%22%3A%222021-06-22T17%3A15%3A20Z%22%7D%7D%5D%7D
Goswami, D., Domingo-Lopez, D. A., Ward, N. A., Millman, J. R., Duffy, G. P., Dolan, E. B., & Roche, E. T. (n.d.). Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes. Advanced Science, n/a(n/a), 2100820. https://doi.org/https://doi.org/10.1002/advs.202100820 Cite
