By combining single-cell RNA and B cell receptor sequencing of antigen-specific cells in lymph nodes, spleen, and lungs after influenza infection in mice, researchers identified several germinal center B cell subpopulations and organ-specific differences that persisted over the course of the response.
[Cell Reports]
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Mathew, N. R., Jayanthan, J. K., Smirnov, I. V., Robinson, J. L., Axelsson, H., Nakka, S. S., Emmanouilidi, A., Czarnewski, P., Yewdell, W. T., Schön, K., Lebrero-Fernández, C., Bernasconi, V., Rodin, W., Harandi, A. M., Lycke, N., Borcherding, N., Yewdell, J. W., Greiff, V., Bemark, M., & Angeletti, D. (2021). Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells. Cell Reports, 35(12). https://doi.org/10.1016/j.celrep.2021.109286 Cite
