Scientists used a temporally restricted model of hepatic repair in which large-scale hepatocyte injury and regeneration were initiated through the acute loss of Mdm2 in hepatocytes, resulting in the rapid, coordinated proliferation of biliary epithelial cells.
[Science Signaling]
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Minnis-Lyons, S. E., Ferreira-González, S., Aleksieva, N., Man, T. Y., Gadd, V. L., Williams, M. J., Guest, R. V., Lu, W.-Y., Dwyer, B. J., Jamieson, T., Nixon, C., Hul, N. V., Lemaigre, F. P., McCafferty, J., Leclercq, I. A., Sansom, O. J., Boulter, L., & Forbes, S. J. (2021). Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation. Science Signaling, 14(688). https://doi.org/10.1126/scisignal.aay9185 Cite
