Tag results:
IGF1R
Mammary Cell News
Procr Functions as a Signaling Receptor and Is Essential for the Maintenance and Self-Renewal of Mammary Stem Cells
[Cell Reports] By conditional knockout in mammary stem cells, investigators demonstrated that protein C receptor (Procr) is essential for mammary gland development and homeostasis.
Intestinal Cell News
Lepr+ Mesenchymal Cells Sense Diet to Modulate Intestinal Stem/Progenitor Cells via Leptin–Igf1 Axis
[Cell Research] The authors demonstrated that Lepr+ MSCs surrounding intestinal crypts sensed diet change and provided a novel niche signal to maintain intestinal stem cell and progenitor cell proliferation.
Pancreatic Cell News
Smoothened (SMO) Regulates Insulin-Like Growth Factor 1 Receptor (IGF1R) Levels and Protein Kinase B (AKT) Localization and Signaling
[Laboratory Investigation] Investigators provided evidence that elevated levels of human SMO showed a strong correlation with elevated levels of insulin-like growth factor 1 receptor and reduced survival in diffuse large B-cell lymphoma.
Dermal Cell News
Overexpression of miR-122 Promotes Apoptosis of Dermal Papilla Cells by Directly Targeting IGF1R in Androgenetic Alopecia
[Cell Biology International] Researchers suggested that upregulation of miR-122 induced apoptosis, potentially via the repression of insulin-like growth factor 1 receptor (IGF1R) in human dermal papilla cells of androgenetic alopecia.
Extracellular Matrix News
Ten-Gene Signature Reveals the Significance of Clinical Prognosis and Immuno-Correlation of Osteosarcoma and Study on Novel Skeleton Inhibitors Regarding MMP9
[Cancer Cell International] The authors identified novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9.
ESC & iPSC News
Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3
[Advanced Science] A low-cost protocol for cardiomyocyte differentiation from mouse ESCs is presented and it is shown that Pten deletion potently suppressed cardiomyocyte differentiation.