Scientists discuss the possible mechanisms responsible for endoplasmic reticulum (ER) proteostasis imbalance with a focus on type II diabetes mellitus, in which both genetics and environment are considered important in promoting ER stress in β-cells.
[Nature Reviews Endocrinology]
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Yong, J., Johnson, J. D., Arvan, P., Han, J., & Kaufman, R. J. (2021). Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus. Nature Reviews Endocrinology, 1–13. https://doi.org/10.1038/s41574-021-00510-4 Cite
